PAIN RELIEF: What Is CBDA And What Are the Benefits of This Cannabinoid?

Leafly.com reports:

CBDA (cannabidiolic acid) is one of many compounds produced by cannabis and hemp. Abundant in the live plants of CBD varieties, it converts to the better known cannabinoid CBD (cannabidiol) over time and when exposed to heat.

Cannabinoids are cannabis compounds that interact with our bodies to produce medical and recreational effects, from pain and stress relief to euphoria. You’ve likely heard of CBD and THC—these are the most widely known cannabinoids, and both originally stem from the precursor “mothership” cannabinoid known as CBGA (cannabigerolic acid).

Potential Medical Benefits of CBDA

While most cannabinoids bind directly with either the CB1 or CB2 receptors, CBDA doesn’t work in this way. Instead, CBDA interacts with the endocannabinoid system by inhibiting the cyclooxygenase-2 (COX-2) enzyme. COX-2 enzymes are associated with inflammation after an injury or infection, so by blocking COX-2 enzymes, CBDA can relieve inflammation and associated pain.

In one rodent study, scientists found CBDA affected levels of serotonin, a chemical produced by nerve cells to aid in signaling between cells. Serotonin is vital to core human functions like motor skills, sleeping, eating, digestion, and emotions.

In the same way that it controls nausea, CBDA may also be a powerful anticonvulsive. In fact, scientists have shown that CBDA has 100 times the affinity for the 5-HT receptors compared to CBD; one reason is that CBDA has greater bioavailability, so the body can metabolize the compound with less effort and in less time.

This same receptor affinity could also mean that CBDA could perhaps effectively fight depression. After all, CBDA works on the 5-HT receptors in much the same way as a selective serotonin reuptake inhibitor (SSRI) antidepressant medication would.

To date, most CBDA studies are preclinical non-human studies. While human trials are needed, some medical cannabis companies like British-based GW Pharmaceuticals are paving the way. GW Pharmaceuticals manufactures a pharmaceutical-grade CBD oil called Epidiolex, the first cannabis-derived prescription drug to be approved by the US Food and Drug Administration (FDA).

Learn more HERE.

10 Exercises To Undo The Spinal Damage Caused By Sitting

Healthy and Natural World reports:

According to a study published in the American Journal of Epidemiology, the average person spends more than half of his or her waking hours in activities that require sitting (watching TV, commuting to and from work, sitting at a computer, etc).

According to a scientific report published in the medical journal, Current Cardiovascular Risk Rep, sitting too much can be as harmful as secondhand smoking.

Some studies show a correlation between sitting too much and higher rates of chronic diseases such as type 2 diabetes, kidney disease, and heart disease. Sitting too much is even linked to early death.

Sitting too much can also damage your back and it is linked to chronic back pain and poor posture.

You can prevent the harmful effects of sitting by doing the following 10 stretches on a regular basis. These 10 yoga stretches can help you increase strength and flexibility, and prevent pain in your back and knees.

Why Yoga Stretches Can Undo the Damage of Sitting Too Much

Yoga has been originated in India and has been practiced for thousands of years. This ancient mind-body practice became part of our modern days and symbolizes peace and well-being. Nowadays more than 20 million Americans practice yoga according to the 2012 Yoga in America study.

Many studies have been published on yoga that suggest that it is an effective way to increase physical activity, especially strength, flexibility, breathing and balance, as well as reduce stress and increase mental abilities. According to HNS website, there is even some evidence that regular yoga practice is beneficial for people with high blood pressure, heart disease, aches and pains.

Read more HERE.